Abstract: The article contains an attempt to position the theoretical publications of Ukrainian scientists in the discourse of adaptation of the enterprise development theory to the conditions of the post-industrial economy, which should ensure the clarification of both the scope of the possible application of the concept of «ecological business systems» for the development of domestic managerial practices, and contribute to the harmonization of the conceptual foundations of the domestic management with modern trends in the development of strategic management of developed countries. The methodological foundations of the article are formed by three basic principles. First, there is a fundamentally different nature of the manifestation of the scale effect for organizations that differ by the place of innovative activity in the system of factors of their competitiveness and, accordingly, by the priority of investing in human capital. Secondly, the dependence of the intensity of STP’s potential using in a certain business organization on its belonging to the «intersectoral network of extracting economic benefits from the STP’s achievements» and its ability to achieve the organicity of the internal environment for the formation of management decisions with the space for the movement of information (ideas, leading experience, decision-making procedures and production efficiency standards) formed within such a network. Thirdly, the combination of technological and institutional concepts of assessing the organization’s potential, which involves the study of actual business results as a consequence of deviation from the technologically achievable optimum, due to the shortcomings of institutional capacity.

As a result, a theoretical substantiation of the ecosystem concept ability «to program the reproduction of the production network» was obtained, taking into account the complex social and ecological consequences of structural changes, allowing to formulate the goals and criteria of the organization’s development in harmony with the principles of the development of the entire economic environment, thanks to the joint extraction of benefits from the «coevolution» of business structures in the national economy. At the same time, it is the works of domestic scientists gives this concept a qualitatively new content, synthesizing its position with the principles of human-centeredness and the priority of preserving the complexity of the structure of the business ecosystem, as the basis for generating a synergistic effect.