Abstract: The article addresses the issue of optimizing business relocation management in the face of contemporary economic and social challenges. Special attention is given to the application of qualimetric approaches for comprehensive evaluation of business relocation management effectiveness. The study highlights that traditional analysis methods, primarily focused on financial indicators, do not sufficiently consider important qualitative factors such as socio-cultural aspects, employee adaptation, and communication with stakeholders. The use of qualimetrics enables the integration of qualitative and quantitative approaches for a thorough assessment of various aspects of relocation. The article presents a methodology based on the use of T. Saaty’s hierarchy algorithm to determine the weight coefficients of different resources (material, financial, human, technological, and managerial). This allows for a systematic evaluation of resource importance in the relocation process and their optimization to achieve the company’s strategic goals. The main focus is placed on areas requiring further research, particularly risk analysis, evaluation of communication strategies’ effectiveness, and change management in new conditions. The study’s findings emphasize the importance of careful pre-relocation planning, consideration of the legal, economic, and cultural characteristics of the new region, as well as effective personnel management and adaptation to new circumstances. The application of qualimetric methods helps businesses minimize relocation-related risks and improve resilience and competitiveness in new markets. The article provides recommendations for businesses on improving relocation management approaches, particularly through the implementation of comprehensive resource assessments and risk mitigation strategies. This ensures successful business operations in changing environments, enhances management quality, and contributes to achieving strategic goals. The development of a specialized methodology for relocation assessment can serve as a foundation for further research and practical applications in business management.