Abstract: The article examines a comprehensive set of factors influencing the antifragility of business organizations under conditions of global instability. Using a systemic approach, the study analyzes economic, political and legal, socio-cultural, technological and innovation, as well as ecological and global determinants that shape the ability of enterprises not only to resist destructive external impacts but also to transform crises into drivers of development. It is demonstrated that antifragility should be understood as an integrative property arising from the synergy of multidimensional factors that convert uncertainty into strategic opportunities. Special emphasis is placed on the Ukrainian context, where wartime challenges and economic turbulence have intensified the need for antifragile strategies of organizational transformation. The findings of the study have practical significance for the development of managerial decisions aimed at strengthening resilience, adaptive capacity, and competitiveness of enterprises in the long-term perspective