Abstract: The article is devoted to the study of the interaction of business environment entropy and risk determinants in the context of external relocation of Ukrainian enterprises in the global space. It is substantiated that the full-scale war caused a sharp increase in uncertainty, disruption of production processes and transformation of value chains, which actualized relocation as a key mechanism for ensuring the stability and adaptability of business. A qualimetric approach to the quantitative assessment of relocation vulnerability is proposed, which combines the analysis of entropic characteristics of the environment, risk groups and adaptive capacity of the enterprise. The relocation of enterprises on a global scale has a multi-vector nature and is formed under the influence of a complex of risks — political, economic, technological, logistical and social — which act as determinants of making management decisions regarding the relocation of production or business offices abroad.Based on factor and cluster analysis, the main institutional, market, financial and social parameters of host countries that perform the function of anti-entropic factors and determine the degree of predictability and stability of the environment after relocation are identified. An integral indicator of relocation vulnerability is constructed, which allows assessing the nonlinear effect of the interaction of entropy and risks and identifying key determinants of spatial mobility of enterprises. It is shown that relocation is not only a reaction to crisis conditions, but also a strategic tool for forming new development trajectories and integration into international business ecosystems. The results obtained form a methodological basis for developing a state policy to support relocated businesses and optimizing strategic decisions of enterprises in conditions of global turbulence.